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. 2022 Feb 21;13:828161. doi: 10.3389/fphar.2022.828161

FIGURE 2.

FIGURE 2

Serum lipid profiles and atherosclerosis of aortic sinus in the LDLR−/− mice. (A–B) TC and TG levels of serum were detected, n = 8. H&E (C) and Oil Red O staining (E) were used to detect the progress of lipid-rich plaques, magnification ×40, n = 6. (B,D) The areas of lesion were calculated respectively by ImageJ analysis software. Masson staining (G) was used to detect the collagen content followed by the quantification (H), magnification ×100, n = 6. (I–L) Representative photomicrographs of aortic root sections stained with α-SMA (I), and caspase 3 (K) in atherosclerotic plaque followed by the quantification (J,L), magnification ×200, n = 6. CON means control group, MOD means model group, AS-IV means Astragaloside IV group, ATO means Atorvastatin group. TC, total cholesterol; TG, triglyceride; ND, not detected; RATIO = plaque area/aortic sinus lumen area ×100%. Data are expressed as mean ± SD. **p < 0.01 versus CON group; #p < 0.05, ##p < 0.01 versus MOD group.