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. 2022 Feb 21;13:828161. doi: 10.3389/fphar.2022.828161

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Copyright © 2022 Zhang, Du, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transaminase, liver lipogenesis and hepatic steatosis in the LDLR^−/− mice. (A,B) ALT and AST levels of serum were detected, n = 8. (C,D) Hepatic TC and TG levels were detected by colorimetric enzymatic kits, n = 8. (E) Representative histological change of steatosis in liver sections stained with H&E, magnification ×400. CON means control group, MOD means model group, AS-IV means Astragaloside IV group, ATO means Atorvastatin group. ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride. Data are expressed as mean ± SD. **p < 0.01 versus CON group; ##p < 0.01 versus MOD group.