Table 2. Comparison of coagulation parameters between ascites and plasma of the same patients as well as plasma of patients with grade 3 ascites and plasma of patients without ascites in cohort A.
| Coagulation parameters | Patients with grade 3 ascites, n = 25 | Patients without ascites, n = 25 |
|||
|---|---|---|---|---|---|
| Ascitic fluid | Plasma | p -Value a | Plasma | p -Value b | |
| EV-TF activity, pg/mL | 5.79 (4.78–8.01) | 0.18 (0.00–0.72) | <0.001 | 0.15 (0.08–0.29) | 0.946 |
| FII activity, % | 9 (5–14) | 59 (44–65) | <0.001 | 54 (48–63) | 0.662 |
| FV activity, % | 0 (0–0) | 61 (43–84) | <0.001 | 57 (46–73) | 0.924 |
| FVII activity, % | 8 (5–10) | 44 (32–50) | <0.001 | 44 (35–69) | 0.733 |
| FVIII activity, % | 0 (0–0) | 237 (210–292) | <0.001 | 176 (149–218) | 0.027 |
| FX activity, % | 1 (0–2) | 56 (44–64) | <0.001 | 54 (48–63) | 0.088 |
| TAT complex, µg/mL | 76.9 (47.2–150.7) | 4.88 (2.5–7.5) | <0.001 | 21.9 (7.7–26.8.1) | <0.001 |
| Prothrombin fragment 1 + 2, pmol/L | 1,836 (956–2,796) | 174 (126–262) | <0.001 | 285 (171–349) | 0.018 |
| PAP complex, µg/mL | 10.9 (7.9–14.7) | 0.9 (0.7–1.1) | <0.001 | 0.3 (0.2–0.5) | <0.001 |
| D-dimer, µg/mL | 68.0 (37.8–102.5) | 5.20 (3.8–7.4) | <0.001 | 0.7 (0.5–1.7) | <0.001 |
| α2-antiplasmin (%) | 7 (7–9) | 59 (51–71) | <0.001 | 58 (52–70) | 0.733 |
| Plasminogen activity (%) | 14 (13–16) | 57 (47–70) | <0.001 | 61 (53–72) | 0.359 |
| PAI-1 (IU/mL) | 0.28 (0.0–1.14) | 0.0 (0.0–1.6) | 0.948 | 0.28 (0.0–2.25) | 0.583 |
| Fibrinogen, mg/dL | 0 (0–0) | 292 (242–325) | <0.001 | 242 (202–296) | 0.051 |
| Peak TG, nM | – | 255 (191–297) | – | 177 (102–248) | 0.018 |
| TG velocity index, nM/min | – | 46.2 (29.5–76.6) | – | 23.9 (11.0–38.8) | 0.005 |
| TG lag phase, min | – | 10.1 (9.1–12.6) | – | 12.1 (10.6–15.6) | 0.047 |
| TG AUC/ETP, nM x min | – | 2,654 (2,159–3,170) | – | 2,886 (2,404–3,123) | 0.734 |
| PT, % | – | 57 (51–66) | – | 58 (57–69) | 0.397 |
| APTT, s | – | 40 (38–45) | – | 41 (37–46) | 0.741 |
Abbreviations: APTT, activated partial thromboplastin time; AUC, area under the curve; ETP, endogenous thrombin potential; EV-TF, extracellular vesicle-associated tissue factor activity; F, coagulation factor; PAI-1, plasminogen activator inhibitor-1; PAP, plasmin-α2-antiplasmin; PT, prothrombin time; TAT, thrombin–antithrombin; TG, thrombin generation.
Note: Data are reported as median (interquartile range [IQR]) and were analyzed by the Kruskal–Wallis test.
a
Plasma vs. ascitic fluid.
b
Plasma of patients with grade 3 ascites vs. plasma of patients without ascites.