Table 2.
Different HRR reversion mutations across different cancer types.
| Total HRR genes | BRCA1 | BRCA2 | PALB2 | Other HRR genes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cancer type | Patients with HRR germline mutations | Patients with reversions | Reversion frequency | Patients with HRR germline mutations | Patients with reversions | Reversion frequency | Patients with HRR germline mutations | Patients with reversions | Reversion frequency | Patients with HRR germline mutations | Patients with reversions | Reversion frequency | Patients with HRR germline mutations | Patients with reversions |
| Lung cancer | 313 | 1 | 0.3% | 28 | 0 | 0.0% | 75 | 1 | 1.3% | 22 | 0 | 0.0% | 188 | 0 |
| Breast cancer | 100 | 8 | 8.0% | 26 | 4 | 15.4% | 39 | 3 | 7.7% | 14 | 1 | 7.1% | 23 | 0 |
| Ovarian cancer | 94 | 3 | 3.2% | 59 | 3 | 5.1% | 22 | 0 | 0.0% | 0 | 0 | NaN | 13 | 0 |
| Pancreatic cancer | 16 | 1 | 6.2% | 2 | 0 | 0.0% | 8 | 1 | 12.5% | 1 | 0 | 0.0% | 5 | 0 |
| Total patient | 654* | 11** | 1.7% | 130*** | 5** | 3.8% | 144 | 5 | 3.5% | 49 | 1 | 2.0% | 305**** | 0 |
* 6 patients with multiple primary cancers. ** 2 patients with breast and ovarian dual primary cancers, both harboured BRCA1 reversion mutation. *** 4 patients with two primary cancers: 3 cases of breast and ovarian dual cancers, 1 case of ovarian and cervical dual cancers. **** 2 patients with two primary cancers: 1 case of ovarian and endometrial dual cancers, and 1 case of lung and cervical dual cancers.