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. 2022 Feb 7;13(4):1313–1323. doi: 10.7150/jca.65444

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PHLPP2 is downregulated in CRC and associated with poor prognosis. (A) The result of immunohistochemical staining of the tissue microarray. (B) Representative immunohistochemical expression patterns of PHLPP2 in cancerous and adjacent normal specimens are shown (magnification×200). (C) Percentage of cases with different staining intensities of PHLPP2 in the tumor or adjacent normal tissues in the study cohort, **P < 0.01. (D) CRC patients were stratified based on the immunoreactive score of PHLPP2 (IRS 0, 1, 2, 3, 4, 6, 8, 9, 12). (E) CRC patients were stratified based on expression of PHLPP2 (IRS≤3 low expression, IRS>3 high expression).