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. 2022 Feb 7;13(4):1313–1323. doi: 10.7150/jca.65444

Figure 5.

Figure 5

Overexpression of PHLPP2 increases ROS levels and inhibits the stemness of CRC cells. (A) The effect of PHLPP2 overexpression on ROS levels in CRC cell lines. (B) Flow cytometry was used to detect the proportion of CD133+ cells in colon cancer cell lines before and after PHLPP2 knockdown and overexpression. (C) Overexpression of PHLPP2 inhibits the formation of stem cell microspheres in CRC cell lines. (D) Overexpression of PHLPP2 enhances the effect of 5-FU on CRC stem cells. (E) Overexpression of PHLPP2 reduced half lethal concentrations of 5-FU and oxaliplatin. (F) The effect of PHLPP2 overexpression on the migration and invasion of CRC cells. (G) The effect of PHLPP2 overexpression on the scratch healing ability of colorectal cancer cells. (H) Subcutaneous tumorigenesis in nude mice with comparison of tumor dissection and tumor volume. For all, *P < 0.05; **P < 0.01; ***P < 0.001.