Fig. 4.

Peroxiredoxin 3 (Prdx3) deficiency reduces mitophagy in the heart.

(A and B) Representative images (A) and quantification (B) of mitophagy in the hearts of 10-week-old Prdx3 wild-type (Prdx3 WT; n = 9), 52-week-old Prdx3 WT (n = 6), 10-week-old Pink1-deficient (Pink1 KO; n = 7), 52-week-old Pink KO (n = 6), 10-week-old Prdx3-deficient (Prdx3 KO; n = 8), and 52-week-old Prdx3 KO (n = 6) mitochondria-targeted Keima (mt)-Keima mice. Scale bar, 10 μm. (C and D) Representative images (C) and quantification (D) of mitophagy in the infarcted hearts of Prdx3 WT (n = 5) and Prdx3 KO mt-Keima mice (n = 7) 1 day after the induction of myocardial infarction (MI). Scale bar, 10 μm ***P < 0.001. . (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)