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. 2022 Jan 20;31(3):179–190. doi: 10.1136/bmjqs-2021-013910

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Actual versus predicted percentage change in the rate of prescriptions following drug safety advisories without dose-related advice,* adjusted by change in controls without an advisory. *Actual versus predicted percentage change in the number of prescriptions written or dispensed per 100 000 population during an 11-month period following the month a drug advisory was issued. Created by the authors. IV, inverse variance; PML, progressive multifocal leucoencephalopathy.