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. 2022 Feb 21;13:857289. doi: 10.3389/fphar.2022.857289

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Copyright © 2022 Wang, Chang, Wang, Wu, Huang, Sun, Liu, Yu and Mao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI network was constructed to screen the key genes of immune function. (A–C) Interaction network constructed with the nodes with interaction confidence value > 0.5. The color of the nodes in the PPI network reflects the log(FC) value of the Z value of gene expression, and the size of the nodes represents the number of proteins interacting with the specified protein. (D–F) Top 10 GO terms of the mode gene in figure A. False discovery rate (FDR) of GO analysis was acquired from DAVID functional annotation tool, p < 0.05.