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. 2021 Nov 11;30(3):1329–1342. doi: 10.1016/j.ymthe.2021.11.007

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Dgat2-1473 silences the human Dgat2 transcript in human hepatocyte-engrafted NSG-PiZ mice

(A) Experimental procedure for generating human hepatocyte-engrafted NSG-PiZ mouse model. (B) Human serum albumin levels in the plasma of these engrafted mice were determined after being randomized from the study groups. (C) Immunostaining of liver sections for human albumin for confirmation of engraftment. (D) Mouse Dgat2 mRNA levels 1 week after injection (E) HumanDGAT2 mRNA levels 1 week after the injection of mice(n = 3) with Dgat2-1473. ∗p < 0.05, ∗∗p < 0.005, ∗∗∗p < 0.0005, ∗∗∗∗p < 0.00005.