Skip to main content
. 2021 Nov 11;30(3):1329–1342. doi: 10.1016/j.ymthe.2021.11.007

Figure 6.

Figure 6

Targeting liver DGAT2 by Dgat2-1473 in genetically obese NASH mice causes downregulation of major genes in the fatty acid metabolism pathway, correlating with a decrease in SREBP1c processing and ChREBP protein expression

(A) Heatmap representation of DE liver genes in fatty acid metabolism pathway (major DNL genes in the pathway highlighted by the black arrows). (B) qPCR confirmation of the RNA-seq data for important genes in fatty acid metabolism pathway. ∗p < 0.05, ∗∗p < 0.005, ∗∗∗p < 0.0005, ∗∗∗∗p < 0.00005. (C) Measurements of both unprocessed (cytosolic) and processed (nuclear) SREBP1c protein levels in liver. (D) ChREBP protein level measurements in liver. ∗p < 0.05, ∗∗p < 0.005, ∗∗∗p < 0.0005, ∗∗∗∗p < 0.00005.