Figure 8.

Dgat2 silencing does not significantly alleviate the inflammation and fibrosis in the liver of genetically obese NASH mice

Ten-week-old genetically obese ob/ob mice (n = 4) were injected subcutaneously with either NTC (10 mg/kg) or Dgat2-1473 (10 mg/kg) and provided a NASH-inducing diet (GAN diet) for 3 weeks. After 3 weeks, mice were sacrificed. (A) Histological examination of fibrosis via trichrome staining and type 1 collagen IHC. (B) Type I collagen protein levels in whole-liver tissue. (C) Plasma ALT measurements. (D) Inflammation and fibrosis related gene expression levels. ∗p < 0.05, ∗∗p < 0.005.