Table 2.
Cox proportional hazards model of all seven atherothrombotic biomarkers for the prediction of atherosclerotic cardiovascular disease risk
| Variable | Hazard ratio (95% CI) | P-value |
|---|---|---|
| Plasminogena | 0.98 (0.82, 1.18) | 0.86 |
| OxPL-plasminogenb | 0.63 (0.53, 0.74) | <0.0001 |
| Fibrinogena | 2.88 (1.99, 4.17) | <0.0001 |
| Plasmin–antiplasmin complexb | 1.20 (0.95, 1.52) | 0.12 |
| D-dimerc | 1.63 (1.32, 2.00) | <0.0001 |
| Factor VIIId | 1.45 (1.20, 1.76) | <0.0001 |
| Lp(a)a | 1.03 (0.97, 1.10) | 0.36 |
Prior to estimating models, each biomarker was log-transformed. Cross-validation estimated C-index = 0.603. Table presents individual biomarker associations following adjustment for all other variables included in the model.
CI, confidence interval; Lp(a), lipoprotein(a); OxPL, oxidized phospholipids.
a
Log(mg/dL).
b
Log(nM).
c
Log(μg/mL).
d
Log(calibrated %).