Table 5.
Multivariable Cox proportional hazards model for atherosclerotic cardiovascular disease events with main effects for each covariate that is included in the pooled cohort equations model as well as thrombotic factor and fibrinolytic factor
| Variable | Hazard ratio (95% CI) | P-value |
|---|---|---|
| Male sex | 1.60 (1.37, 1.87) | <0.0001 |
| Race | ||
| White | ||
| Chinese | 0.72 (0.57, 0.92) | 0.009 |
| Black | 0.79 (0.66, 0.94) | 0.01 |
| Hispanic | 0.96 (0.81, 1.15) | 0.66 |
| Age, years | 1.04 (1.03, 1.05) | <0.0001 |
| Total cholesterol, mg/dL | 1.003 (1.001, 1.005) | 0.005 |
| HDL, mg/dL | 0.998 (0.983, 0.994) | <0.0001 |
| Systolic BP, mmHg | 1.011 (1.008, 1.014) | <0.0001 |
| Diabetes | 1.77 (1.50, 2.09) | <0.0001 |
| Smoking status | ||
| Never | ||
| Former | 1.51 (1.22, 1.88) | 0.05 |
| Current | 1.34 (1.16, 1.55) | 0.0002 |
| Hypertension medications | 1.36 (1.18, 1.57) | <0.0001 |
| Thrombotic factora | 1.28 (1.17, 1.40) | <0.0001 |
| Fibrinolytic factora | 0.87 (0.81, 0.95) | 0.001 |
Cross-validation estimated C-index = 0.721. The table presents individual associations following adjustment for all other variables included in the model.
CI, confidence interval; HDL, high-density lipoprotein; BP, blood pressure.
a
Standardized unit.