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. 2022 Jan 31;12(5):2041–2062. doi: 10.7150/thno.68636

Figure 6.

Figure 6

Phage display derived peptides targeting tau and their applications characterization. (A) Tau isoform hTau40, Tau constructs K18, K18ΔK and K18ΔKAA. hTau40 is the longest human Tau isoform. hTau40 and K18 contain four repeats designated R1 to R4. Deletion and mutations in the constructs K18 and K18ΔKAA are indicated in red. The positions of the hexapeptide motifs PHF6, PHF6*, and PHF6** are highlighted in yellow. (B) NMR of the K18-TP4 interaction. 1H-15N HSQC spectra of K18ΔKAA in the absence (red) and presence (blue) of TP4. (C) ThT monitored kinetic curves for K18ΔKAA alone (black), K18ΔKAA with TP4 atstoichiometric (blue) and substoichiometric (magenta) concentration. (D) TEM of K18ΔKAA samples and with addition of TP4. (E) Binding mode of D-enantiomeric peptide p-NH with the PHF6 fibrils. (F) Representative images of nest construction. p-NH treatment rescued the nest construction ability of APP/PS1 Tg mice during 6 consecutive days of observation. (A-D) licensed under a Creative Commons Attribution (CC BY) license. (E, F) Reprinted with permission from 59. Copyright 2020 American Chemical Society.