Table 1.

KD of the 8 most promising compounds for Bcl-2, Bcl-xL and Mcl-1 proteins. * Two compounds most investigated in the study. The chemical structures of IS20 and IS21 are also depicted.

COMPOUND	Bcl-2 (µM)	Bcl-xL (µM)	Mcl-1 (µM)
IS20: R1 = -CH2-CH2-CH2-CH3 IS21: R1 = -CH2-CH2-CH2-CH2-CH3
IS21*	0.19 ± 0.07	0.51 ± 0.17	1.16 ± 0.14
IS20*	0.32 ± 0.09	0.42 ± 0.09	3.9 ± 0.30
IS1	0.48 ± 0.11
ISQ	0.53 ± 0.10
ISP	0.77 ± 0.14
IS29	3.40 ± 1.10
IS9	4.00 ± 0.70
IS27	4.60 ± 0.90