Figure 1.

Summary of the action mechanism of cisplatin. (A) Mechanism of action of cisplatin comprising (i) cellular uptake, (ii) aquation/activation, (iii) DNA platination, and (iv) cellular processing leading to apoptosis. Adapted with permission from ref 44, copyright 2016 American Chemical Society. (B) Alternative effects of cisplatin. Other interesting mechanisms such as acidification of the cytoplasm, ER stress, disruption of RNA transcription, inhibition of important oncogenic proteins, and decrease in metabolic plasticity of cancer cells as well as changes in their mechanobiology. Adapted with permission from ref 46, copyright 2019 Royal Society of Chemistry.