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. 2022 Feb 14;12(5):2205–2231. doi: 10.7150/thno.70756

Figure 5.

Figure 5

PBM treatment recruits microglia surrounding amyloid plaques by regulating astrocytic IL-3 and microglial IL-3Rα. (A) Representative immunofluorescence staining and 3D reconstruction of Iba-1 (green) and Aβ (4G8, red) in both cortex and hippocampus (a). Microglial count around amyloid plaques (b) and the colocalization between microglia and Aβ deposition (c) were analyzed. (B) Representative immunofluorescence images showing co-localization of IL-3Rα (red) and Iba-1 (green) in proximity to amyloid plaques in both the cortex and hippocampus (a). The number of IL-3Rα-positive microglia in the cortex (b) and (c) was analyzed. (C) Representative images showing co-localization of IL-3 (red) and GFAP (green) in both the cortex and hippocampus. Scale bar = 20 µm. Data are presented as mean ± SEM (n = 6). *P < 0.05.