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. 2022 Feb 21;12(5):2266–2289. doi: 10.7150/thno.66663

Figure 1.

Figure 1

Ferroptotic stress emerges in macrophages after bacterial infection. (A) Increase in ferrous iron in macrophages infected by E. coli or S. aureus at 6 h. FeRhoNoxTM-1 probe-stained ferrous iron. DAPI-stained cell nucleus. Scale bar = 20 µm. (B-D) Changes in intracellular iron level after bacterial infection in macrophages. (E-G) GSH balance in cells infected by bacteria in macrophages. (H) Lipid peroxide level in macrophages infected by bacteria. BODIPY 581/591-C11 probe was used to detect lipid ROS. (I) Changes in MMP in macrophages after bacterial invasion. n = 3, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.