Figure 2.

PRISMA diagram of the scoping review

Results from an initial search of PubMed with keywords—("gene therapy" OR "gene transfer" OR viral-vector OR Chemogenetics OR Pharmaco-genetic OR DREADD OR hM3D OR hM4D OR PSAM OR PSEM) AND (model)—for original articles published before May 1, 2021, were combined with author contributions. Two authors independently screened study titles and abstracts to select relevant articles. The full texts of relevant articles were assessed to determine article eligibility based on three criteria, which required (i) application(s) of chemogenetic tools in (ii) model(s) of neuropsychiatric diseases and disorders that (iii) reduced disease-/disorder-associated phenotypes. Differences between the two authors were arbitrated by a third author.