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. 2022 Jan 7;30(3):1188–1200. doi: 10.1016/j.ymthe.2022.01.007

Figure 5.

Figure 5

NALM6-mIDH1 cancer cells inhibit the killing potential of CAR-T cells

(A) The percentage of lysed cancer cells after co-culture for 48 h of D2HGDH-modified CAR-T cells with NALM6 cancer cells in the additional 500 μM D2HG medium.

(B) The percentage of lysed cancer cells after co-culture for 48 h of D2HGDH-modified CAR-T cells with NALM6-mIDH1 cancer cells in normal medium.

(C) The intracellular fold change of D2HG in the resident cells after co-culture for 48 h of D2HGDH -modified CAR-T cells with NALM6 cancer cells in the additional 500 μM D2HG medium.

(D) The intracellular fold change of D2HG in the resident cells after co-culture for 48 h of D2HGDH-modified CAR-T cells with NALM6-mIDH1 cancer cells in normal medium. The data and statistical results are in Table S5.