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. 2022 Jan 5;30(3):1343–1351. doi: 10.1016/j.ymthe.2022.01.005

Figure 2.

Figure 2

Precise editing by compact PE3 at endogenous loci

(A) Comparison of precise editing and indel efficiency for substitutions and insertions induced by RT362, RT474, RT497, and PE3 at FANCF, VEGFA, RNF2, and HEK3 loci in HEK293T cells. (B) Left: schematic of single nucleotide substitution at positions +1, +12, and +30 of HEK3. Right: comparison of precise editing efficiency for single nucleotide substitution at positions +1, +12, and +30 of HEK3 by RT474, RT497, and PE3. Results were obtained from three independent experiments (RT474) or four independent experiments (RT362, RT497, PE3), shown as mean ± SD. NS, not significant; ∗p < 0.05; ∗∗∗p < 0.001.