Table 2.

Comparison of nephrotoxicity markers between the three groups during the 10-day study

Parameter	Baseline		Day 3		Day 5		Day 7		Day 10		P value of linear trend time
	uNGAL	CrCL	uNGAL	CrCL	uNGAL	CrCL	uNGAL	CrCL	uNGAL	CrCL	uNGAL	CrCL
LT (n=7)	11.1±8.6	74.5±22.7	18.8±24.8	78.9±23.5	27.8±31.7	78.8±30.8	34.0±37.7	81.9±23.7	16.7±14.4	86.5±28.0	0.364	0.562
MT (n=16)	23.3±23.1	57.4±13.4	41.2±29.9	59.5±15.6	56.4±36.2	58.7±15.9	59.5±39.4	60.5±15.0	61.9±32.2	57.9±14.9	0.007	0.916
HT (n=10)	31.3±35.2	57.8±13.8	70.2±36.8	55.0±15.0	86.6±30.5	48.3±13.4	74.8±26.7	42.4±5.8	80.8±28.0	45.2±12.4	0.002	0.046
P value*	0.209	0.226	0.005	0.079	0.008	0.070	0.189	0.002	0.010	0.012	–	–

All the continuous variables are presented as mean±SD. P value^* is the p value for comparisons of the parameters between the three groups at each time point.

CrCL, creatinine clearance; HT, high trough; LT, low trough; MT, moderate trough; uNGAL, urine neutrophil gelatinase-associated lipocalin.