FIGURE 1.

Representative intracerebral recording from the prefrontal cortex of a control mouse (A) and PH-Tau-Tg mouse (C). Recordings were performed for 15 min (baseline) followed by an i.p. injection of insulin (1IU) at 10 min later and KA (5 mg/kg) at t25. Onset of high frequency discharge and ictal activity occurred about 20 to 30 min post KA injection. In controls, once seizures occurred there was no recovery and the amplitude of the population spikes almost doubled and remained so for the duration of the recordings. In PH-Tau-Tg mice the latency was the same as controls, however, the amplitude of the population spikes was significantly lower and ictal activity was intermittent and interrupted with interictal events (C). Spike histograms analysis of firing rates with a detection threshold of 0.1 mv and a Bin size of 1 s showed a significant increase after KA injection in controls (B) and drastic decrease post KA-injection in PH-Tau-Tg mice (C) (n = 3 of each group) Shown here are representative intracerebral recordings from individual mice.