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. 2022 Feb 21;13:752189. doi: 10.3389/fimmu.2022.752189

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Copyright © 2022 Zhu, Tang, Xu, Wu, Liu, Geng, Ma, Tsao, Feng and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNASE2 promoted the secretion of IL-10 from lupus monocytes. (A) Flow cytometry sorting technology was used to separate lupus CD14⁺ monocytes, CD19⁺ B cells, CD4⁺ T cells and the remaining CD14^-CD19^-CD4^- cells. (B) mRNA expression of IL-10 in each cell subgroup was detected by real-time PCR, and the highest expression was seen in monocyte subgroup (n=5), especially those from SLE patients (n=8). (C, D) mRNA expression of RNASE2 was also prominent in monocyte subgroup from lupus patients, which was correlated with monocyte IL-10 mRNA level (by Spearman correlation test, n=8). (E, F) RNASE2 silencing down-regulated IL-10 mRNA expression in lupus monocytes and IL-10 protein levels in cultured supernatants (n=7). Data are presented as mean ± SEM, *p < 0.05, **p < 0.01, ns, no significant statistical difference.