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. 2022 Feb 21;13:752189. doi: 10.3389/fimmu.2022.752189

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Copyright © 2022 Zhu, Tang, Xu, Wu, Liu, Geng, Ma, Tsao, Feng and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-10 regulated the production of ABCs in SLE patients. (A) Lupus B cells were co-cultured with monocytes with the presence of either RNASE2 siRNA (RNASE2si) or RNASE2 siRNA plus 50ng/ml human recombinant IL-10 (RNASE2si+IL-10) (n=6). The proportion of CD11c⁺T-bet⁺ B cells was restored after the replenishment of IL-10 in RNASE2 silencing group. (B) High dose anti-IL-10 (5ug/ml) but not low dose anti-IL-10 (1ug/ml) blocked the production of CD11c⁺T-bet⁺ B cells in B cell and monocyte co-cultures (n=5). (C) The effect of recombinant IL-10 on the proportion of CD11c⁺T-bet⁺ B cells in B-cell plus monocyte co-cultures (n=8). (D) The effect of recombinant IL-10 on the proportion of CD11c⁺T-bet⁺ B cells in CD19⁺ B cell culture (n=5). (E) Hypothesis schema of RNASE2 pathogenetic role involved in SLE patients (picture material was from http://smart.servier.com). Data are presented as mean ± SEM, paired t test, *p < 0.05, **p < 0.01.