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. 2021 Aug 2;7(1):29–37. doi: 10.1136/svn-2021-000987

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Pertussis toxin (PT) increases the permeability of blood–brain barrier after intracerebral haemorrhage (ICH). ICH was induced by 0.0375 U collagenase injection. (A) Representative dorsal surfaces and quantification analysis show the Evans Blue leakage of brain at day 3 after surgeries. n=6 mice per group from three independent experiments. (B, C) Representative immunostaining for CD31 (green) and claudin-5 (red) and MMP-9 (red) in ipsilateral hemisphere from ICH and sham mice treated with 500 ng PT or vehicle at day 3 after onset. White lines delineate lesion area. Scale bar: 50 µm, insert: 25 µm. (D, E) Quantification of claudin-5 and MMP-9 coverage in sham mice and peri-lesion area of ICH mice receiving PT or vehicle at the indicated time. n=9 sections from 3 mice each group. Data were expressed as mean±SEM; *p<0.05; **p<0.01.