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. 2021 Aug 2;7(1):29–37. doi: 10.1136/svn-2021-000987

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Pertussis toxin (PT) augments brain inflammation after brain ischaemia and reperfusion. (A, B) Visualisation of reactive oxygen species generation, in vivo bioluminescence imaging and quantification of signal strength in sham and middle cerebral artery occlusion (MCAO) mice given PT or vehicle at day 3 after ischaemia and reperfusion. n=3 mice per group from two independent experiments. (C) Counts of central nervous system–infiltrating immune cell subsets were measured using flow cytometry on day 3 after reperfusion. Representative flow cytometry plots show the gating strategy of leucocyte subpopulations isolated from the brain. (D) Summarised results show the cell counts of the indicated subsets in the brain of sham and MCAO mice receiving PT or vehicle. n=4 mice per group. The data were calculated as mean±SEM; *p<0.05, **p<0.01.