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. 2021 Aug 2;7(1):29–37. doi: 10.1136/svn-2021-000987

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Pertussis toxin (PT) enhances the permeability of blood–brain barrier after ischaemia. (A) Photographs of the dorsal surfaces of brain display Evans Blue extravasation at day 3 after ischaemia and reperfusion, and quantification of Evans Blue dye leakage at day 3 after surgery in the indicated groups. (B, C) Representative images show staining of CD31 (green) and claudin-5 (red) and MMP-9 (red) in brain sections from middle cerebral artery occlusion (MCAO) and sham mice at day 3 after ischaemia and reperfusion. Infarct areas are outlined in white dotted line. Scale bar: 50 µm, insert: 25 µm. (D, E) Summarised results show the claudin-5 and MMP-9 positive areas covered to the total endothelial surface area (CD31) in the sham mice and peri-infarct of MCAO mice at day 3 after MCAO. n=3 mice in each group from three independent experiments. The data were calculated as mean±SEM; **p<0.01.