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. 2022 Feb 21;13:839464. doi: 10.3389/fphar.2022.839464

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Copyright © 2022 Shi, Hou, Li, Zhou and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ferroptosis pathway was involved in 4HC-treated tumor cells. (A) Dot plots show the enriched terms identified in the KEGG analysis of differentially expressed genes detected in 4HC-treated GL261 cells compared with vehicle-treated cells, and the ferroptosis pathway was altered. (B) Volcano plot showing the upregulated and downregulated genes in response to 4HC treatment measured using RNA-seq. Solid symbols indicate genes in which the differential expression was statistically significant. Red, upregulated genes; green, downregulated genes. (C) Relative expression of the Hmox-1 and Slc7a11 mRNAs in different cell lines treated with 4HC (20 μM) for 6, 12 and 24 h. Data are presented as the means ± SD from more than three independent experiments; *p < 0.05, **p < 0.01, and ****p < 0.001 (one-way ANOVA analysis).