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. 2022 Feb 21;13:839464. doi: 10.3389/fphar.2022.839464

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Copyright © 2022 Shi, Hou, Li, Zhou and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial deformation and 4HC-induced alterations in GSH or iron levels were antagonized by ferroptosis inhibitors (A-B) TEM visualization of changes in mitochondrial morphology in 4T1 cells exposed to various experimental conditions. The red arrows indicate mitochondrial. Shown were representative images with similar results (scale bar = 2.0 μm). (C) Intracellular iron concentrations in 4T1 and GL261 cells exposed to 4HC (20 μM) for the indicated times were determined using ICP–MS. Values are presented as the means ± SD from three independent experiments. ns, not significant, **p < 0.01, and ***p < 0.001 (one-way ANOVA analysis). (D) Intracellular GSH levels in 4T1 and GL261 cells exposed to the indicated conditions were determined. Values are represented as the means ± SD from more than three independent experiments. **p < 0.01 and ***p < 0.001 (one-way ANOVA analysis) for the indicated comparisons.