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. 2022 Feb 21;13:839464. doi: 10.3389/fphar.2022.839464

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Copyright © 2022 Shi, Hou, Li, Zhou and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An HMOX-1 agonist enhanced the chemotherapeutic effect of CTX by inducing ferroptosis. (A) The murine xenograft model was established and treated as described in the text. (B) Tumor weight and volume of each group (n = 6–7) for the indicated times. Data are presented as the means ± SEM. ns, not significant, *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA analysis) for the indicated comparisons (C) Iron content and GSH levels in each group (n = 6–7). Data are presented as the means ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA analysis) for the indicated comparisons (D) Relative Nrf2, Hmox-1, Slc7a11, Fth1 and Ptgs2 mRNA levels in different groups (n = 6–7). Data are presented as the means ± SEM; ns, not significant, *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA analysis) for the indicated comparisons.