The mRNA expression of 5 hub genes by UALCAN and GEPIA2. (A) PMAIP1. (B) NOP14. (C) SHH signaling molecule. (D) BCL2. (E) ZEB2. Red: tumor; blue/green: normal. **** mean P<0.001. GEPIA2, Gene Expression Profiling Interactive Analysis 2; PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1; NOP14, nucleolar protein 14; SHH, sonic hedgehog; BCL2, BCL2 apoptosis regulator; ZEB2, zinc finger E-box binding homeobox 2; COAD, colon adenocarcinoma; TCGA, The Cancer Genome Atlas.