Table 1. Baseline characteristics of all patients in training and validation cohorts.
| Characteristics | Training cohort, n=393 (%) | Validation cohort n=210 (%) | P value |
|---|---|---|---|
| Age, >50 years | 213 (54.2) | 110 (52.4) | 0.670 |
| Gender, Male | 345 (87.8) | 187 (89.0) | 0.647 |
| HBV-DNA, >2,000 IU/mL | 242 (61.6) | 126 (60.0) | 0.705 |
| TBil, >17.1 μmol/L | 70 (17.8) | 34 (16.2) | 0.616 |
| Albumin, <3.5 g/dL | 135 (34.4) | 80 (38.1) | 0.360 |
| ALT, >44 U/L | 177 (45.1) | 77 (36.7) | 0.047 |
| AST, >40 U/L | 218 (55.5) | 114 (54.3) | 0.780 |
| Child-Pugh, B | 8 (2.0) | 7 (3.3) | 0.330 |
| AFP, >400 ng/mL | 248 (63.1) | 144 (68.6) | 0.449 |
| Nonanatomical hepatectomy, yes | 160 (40.7) | 85 (40.5) | 0.955 |
| Surgical margin, <1 cm^ | 130 (33.1) | 71 (33.8) | 0.856 |
| Tumor number, >1^ | 54 (13.7) | 22 (10.5) | 0.250 |
| Tumor diameter, >5 cm^ | 197 (50.1) | 108 (51.4) | 0.681 |
| Bilateral tumor distribution^ | 84 (21.4) | 45 (21.4) | 0.988 |
| Satellite nodules^ | 129 (32.8) | 61 (29.0) | 0.342 |
| Microvascular invasion^ | 123 (31.3) | 83 (39.5) | 0.683 |
| Edmondson-Steiner grade, III-IV | 271 (69.0) | 152 (72.4) | 0.162 |
| Cirrhosis^ | 289 (73.5) | 163 (77.6) | 0.270 |
| TNM stage: I-II, IIIA-IIIB | 306 (77.9), 87 (22.1) | 186 (88.6), 24 (11.4) | 0.001 |
| BCLC stage: 0, A-B | 15 (3.8), 378 (96.2) | 11 (5.2), 199 (94.8) | 0.413 |
| CLIP score: 0-1, 2-3 | 291 (74.0), 102 (26.0) | 101 (48.1), 109 (51.9) | 0.324 |
^, Post-operative parameter. TBil, total bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AFP, α-fetoprotein; TNM, tumor-node-metastasis staging system; CLIP, Cancer of the Liver Italian Program score; BCLC, Barcelona Clinic Liver Cancer staging system.