Table 2. Independent prognostic factors predicting RFS in training cohort.
| Characteristics | Univariate | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age, >50 years | 1.000 | 0.780–1.290 | 0.995 | NA | NA | NA | |
| Gender, Male | 0.820 | 0.540–1.250 | 0.353 | NA | NA | NA | |
| HBV-DNA, >2,000 IU/mL | 1.310 | 1.000–1.700 | 0.046 | 1.400 | 1.060–1.840 | 0.017 | |
| TBil, >17.1 μmol/L | 0.940 | 0.670–1.310 | 0.698 | NA | NA | NA | |
| Albumin, <3.5 g/dL | 1.200 | 0.920–1.550 | 0.176 | NA | NA | NA | |
| ALT, >44 U/L | 1.040 | 0.810–1.340 | 0.759 | NA | NA | NA | |
| AST, >40 U/L | 1.340 | 1.040–1.720 | 0.026 | 0.990 | 0.750–1.290 | 0.916 | |
| Child-Pugh, B | 1.040 | 0.390–2.780 | 0.945 | NA | NA | NA | |
| AFP, >400 ng/mL | 2.320 | 1.750–3.080 | <0.001 | 1.720 | 1.270–2.330 | <0.001 | |
| Nonanatomical hepatectomy | 1.002 | 0.885–1.125 | 0.251 | NA | NA | NA | |
| Surgical margin, <1 cm^ | 1.011 | 0.899–1.094 | 0.136 | NA | NA | NA | |
| Tumor number, >1^ | 2.210 | 1.610–3.050 | <0.001 | 1.160 | 0.830–1.630 | 0.386 | |
| Tumor diameter, >5 cm^ | 2.220 | 1.710–2.870 | <0.001 | 1.100 | 0.830–1.450 | 0.517 | |
| Bilateral tumor distribution^ | 1.105 | 0.856–1.356 | 0.469 | NA | NA | NA | |
| Satellite nodules^ | 1.960 | 1.510–2.540 | <0.001 | 1.390 | 1.060–1.840 | 0.018 | |
| Microvascular invasion | 3.710 | 2.860–4.820 | <0.001 | 2.140 | 1.600–2.850 | <0.001 | |
| Edmondson-Steiner grade, III-IV | 5.530 | 3.820–8.030 | <0.001 | 4.210 | 2.830–6.270 | <0.001 | |
| Cirrhosis^ | 0.860 | 0.650–1.140 | 0.293 | NA | NA | NA | |
^, Post-operative parameter. RFS, recurrence-free survival; TBil, total bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AFP, α-fetoprotein.