Table 5.

Publication bias analysis

	No. of included literatures	OR	P value for OR	P value of Egger’s test
Original data
GI symptom	53	0.88	0.23	0.05
Diarrhea	24	1.01	0.96	0.55
Nausea/vomiting	18	1.16	0.46	0.04
Abdominal pain	9	1.55	0.3	0.61
After trim-and-fill
GI symptom	56	0.84	0.11	0.82
Diarrhea	24	1.01	0.96	0.55
Nausea/vomiting	21	1.02	0.91	0.9
Abdominal pain	11	1.28	0.51	0.94

OR, odds ratio; GI, gastrointestinal