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. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2021 Feb 8;90:137–164. doi: 10.1146/annurev-biochem-080320-110356

Figure 5: Processing enzymes and their DNA substrates.

Figure 5:

An array of end processing enzymes enables NHEJ to repair DSBs with diverse end structures, as shown here. Artemis is shown opening a V(D)J recombination hairpin intermediate (red arrow, cleavage site); its cognate substrates during repair of spontaneous breaks are unclear.