Table 2. Summary of MR features per TMB-based subtypes.
| MR features | Total (n=168) | TMB group | χ2 | P | |
|---|---|---|---|---|---|
| TMB low | TMB high | ||||
| Necrosis | 0.149 | 0.700 | |||
| Negative | 31 (18.45) | 19 (17.59) | 12 (20.00) | ||
| Positive | 137 (81.55) | 89 (82.41) | 48 (80.00) | ||
| Multifocality | 10.388 | 0.001 | |||
| Negative | 161 (95.83) | 108 (100.00) | 53 (88.33) | ||
| Positive | 7 (4.17) | 0 (0) | 7 (11.67) | ||
| Hemorrhage | 0.101 | 0.750 | |||
| Negative | 142 (84.52) | 92 (85.19) | 50 (83.33) | ||
| Positive | 26 (15.48) | 16 (14.81) | 10 (16.67) | ||
| Degree of enhancement | 8.925 | 0.003 | |||
| Negative | 68 (43.04) | 52 (52.00) | 16 (27.59) | ||
| Positive | 90 (56.96) | 48 (48.00) | 42 (72.41) | ||
| Proportion CE tumor | 12.984 | <0.001 | |||
| Negative | 102 (64.56) | 75 (75.00) | 27 (46.55) | ||
| Positive | 56 (35.44) | 25 (25.00) | 31 (53.45) | ||
| Enhancing margin | 0.024 | 0.876 | |||
| Well-defined | 42 (26.58) | 27 (27.00) | 15 (25.86) | ||
| Poorly-defined | 116 (73.42) | 73 (73.00) | 43 (74.14) | ||
| Extranodular growth | 19.49 | <0.001 | |||
| Negative | 129 (81.65) | 92 (92.00) | 37 (63.79) | ||
| Positive | 29 (18.35) | 8 (8.00) | 21 (36.21) | ||
| T1 + C/T2 mismatch | 6.763 | 0.009 | |||
| Negative | 135 (85.44) | 91 (91.00) | 44 (75.86) | ||
| Positive | 23 (14.56) | 9 (9.00) | 14 (24.14) | ||
| CS | 1.744 | 0.187 | |||
| >30 mm | 86 (51.81) | 59 (55.66) | 27 (45.00) | ||
| ≤30 mm | 80 (48.19) | 47 (44.34) | 33 (55.00) | ||
| Location | 5.169 | 0.023 | |||
| Other | 104 (61.90) | 60 (55.56) | 44 (73.33) | ||
| Frontal lobe | 64 (38.10) | 48 (44.44) | 16 (26.67) | ||
| SVZ | 7.413 | 0.006 | |||
| Negative | 59 (35.12) | 46 (42.59) | 13 (21.67) | ||
| Positive | 109 (64.88) | 62 (57.41) | 47 (78.33) | ||
| Volume | 0.162 | 0.687 | |||
| <60 cm3 | 50 (29.76) | 31 (28.70) | 19 (31.67) | ||
| ≥60 cm3 | 118 (70.24) | 77 (71.30) | 41 (68.33) | ||
| Intratumoral vascular | 0.001 | 0.973 | |||
| Negative | 4 (2.53) | 2 (2.00) | 2 (3.45) | ||
| Positive | 154 (97.47) | 98 (98.00) | 56 (96.55) | ||
| Length | 3.303 | 0.069 | |||
| < median | 83 (49.4) | 59 (54.63) | 24 (40.00) | ||
| ≥ median | 85 (50.6) | 49 (45.37) | 36 (60.00) | ||
| Width | 0.043 | 0.836 | |||
| < median | 83 (49.40) | 54 (50.00) | 29 (48.33) | ||
| ≥ median | 85 (50.60) | 54 (50.00) | 31 (51.67) | ||
| Depth | 0.013 | 0.908 | |||
| < median | 83 (49.40) | 53 (49.07) | 30 (50.00) | ||
| ≥ median | 85 (50.60) | 55 (50.93) | 30 (50.00) | ||
| Length-width ratio | 4.192 | 0.041 | |||
| < median | 85 (50.60) | 61 (56.48) | 24 (40.00) | ||
| ≥ median | 83 (49.40) | 47 (43.52) | 36 (60.00) | ||
| Length-depth ratio | 0.305 | 0.581 | |||
| < median | 86 (51.19) | 57 (52.78) | 29 (48.33) | ||
| ≥ median | 82 (48.81) | 51 (47.22) | 31 (51.67) | ||
| Length-depth ratio | 0.014 | 0.907 | |||
| < median | 84 (50.60) | 54 (50.94) | 30 (50.00) | ||
| ≥ median | 82 (49.40) | 52 (49.06) | 30 (50.00) | ||
| Volume | 0.28 | 0.597 | |||
| < median | 83 (49.40) | 55 (50.93) | 28 (46.67) | ||
| ≥ median | 85 (50.60) | 53 (49.07) | 32 (53.33) | ||
MR, magnetic resonance; TMB, tumor mutational burden; CE, contrast-enhanced; CS, the shortest distance between the edge of the lateral and the tumor centroid; SVZ, subventricular zone.