Figure 6.

Association between amount of iLEC in breast cancer and intratumor heterogeneity and mutation rate, and also the immunogenicity and immune cell invasion. Box plots show (A) intratumor heterogeneity, silent and nonsilent mutation rate, fraction altered, and homologous recombination deficiency, and (B) single nucleotide variant (SNV) and Indel neoantigens and tumor-infiltrating lymphocytes (TIL) regional fraction based on scoring by Thorrson et al. using the TCGA cohort. (C) Boxplot shows difference between high and low iLEC breast cancer in the amount of pro-cancer related immune cell infiltration in both TCGA and GSE96058 cohort. Mann-Whitney U test was used to determine statistical significance.