Table 3.
Statistical associations between CCNB2 protein expression and the clinic-pathological factors in Nottingham breast cancer cohort (n=3178)
| Nottingham Breast Cancer Cohort | |||
|---|---|---|---|
|
| |||
| Parameters | CCNB2 protein | ||
|
| |||
| Number % | Mean Rank | P-value | |
| Patient Age (year) | |||
| ≤50 | 1042 (33) | 1672.3 | <0.0001 |
| >50 | 2131 (67) | 1545.3 | |
| Tumour Size | |||
| ≤2 cm | 1768 (56) | 1555.6 | 0.032 |
| >2 cm | 1403 (44) | 1624.3 | |
| Tumour Grade | |||
| 1 | 543 (17) | 1314.0 | <0.0001 |
| 2 | 1131 (36) | 1503.9 | |
| 3 | 1496 (47) | 1745.7 | |
| Mitosis | |||
| 1 | 1284(42) | 1361.82 | <0.0001 |
| 2 | 598 (19) | 1597.05 | |
| 3 | 1211 (39) | 1718.63 | |
| Pleomorphism | |||
| 1 | 58 (1.8) | 1213.87 | <0.0001 |
| 2 | 1084 (35) | 1368.07 | |
| 3 | 1949 (36.2) | 1654.48 | |
| Tubular Formation | |||
| 1 | 205 (6.6) | 1282.29 | <0.0001 |
| 2 | 984 (31.7) | 1510.29 | |
| 3 | 1906 (61.7) | 1596.05 | |
| Lympho-vascular Invasion | |||
| Negative | 2205 (70) | 1549.6 | 0.004 |
| Positive | 954 (30) | 1650.1 | |
| Axillary Nodal Stage | |||
| 1 | 1989 (63) | 1563.5 | 0.136 |
| 2 | 903 (28) | 1607.3 | |
| 3 | 277 (9) | 1666.6 | |
| Nottingham Prognostic Index | |||
| Good | 1041 (33) | 1416.0 | <0.0001 |
| Moderate | 1632 (51) | 1659.3 | |
| Poor | 496 (16) | 1695.0 | |
| Oestrogen Receptor | |||
| Negative | 704 (22) | 1677.0 | 0.001 |
| Positive | 2453 (78) | 1550.9 | |
| Progesterone Receptor | |||
| Negative | 1256 (41) | 1585.5 | 0.007 |
| Positive | 1813 (59) | 1500.0 | |
| HER2 Status | |||
| Negative | 2677 (87) | 1513.8 | <0.0001 |
| Positive | 402 (13) | 1714.3 | |
| Triple Negative | |||
| Negative | 2630 (84) | 1538.7 | 0.007 |
| Positive | 483 (16) | 1656.5 | |
Significant P values are in bold.