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. 2022 Feb 15;12(2):537–548.

Figure 1.

Figure 1

The expression of VEGFD and lymphangiogenesis in Ahrr low and Ahrr high HNC. A. The immunohistochemical images of low and high expression in HNC were analyzed with unrelated IgG as negative control. B. VEGFD concentrations were measured by enzyme immunoassay in HNC tissues. The mean VEGFD concentration was used to calculate the mean VEGFD concentration for Ahrr low and Ahrr high HNC. C. Having shown that VEGFD production in the HNC can be stimulated by hypoxia exposure, we next determined how induction was regulated by the AHRR. D, E. LVD scores and percentage of high or low AHRR expression in tumors. Horizontal lines represent the median. F. Comparison of cumulative five-year survival curves of patients with HNC according to independent AHRR expression-related factors with the Log-rank method. The postoperative survival rate of patients with high expression levels of AHRR was poorer than those with lower expression of AHRR. The scale bar represents 50 μm (P<0.01).