Table 3.
Univariate and multivariate analysis for OS and tumor recurrence
| Characteristic | Overall survival (OS) | Disease-free survival (DFS) | ||||||
|---|---|---|---|---|---|---|---|---|
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| Univariate | Multivariate | Univariate | Multivariate | |||||
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| P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | |
| Sex (female vs. male) | 0.424 | 0.866 (0.609-1.232) | 0.126 | 0.801 (0.602-1.064) | ||||
| Age (≤60 vs. >60) | 0.191 | 1.187 (0.918-1.534) | 0.021 | 1.278 (1.038-1.572) | ||||
| ALB | 0.000 | 0.946 (0.925-0.968) | 0.004 | 0.972 (0.953-0.991) | ||||
| ALT | 0.000 | 1.007 (1.004-1.009) | 0.000 | 1.006 (1.003-1.008) | ||||
| AST | 0.000 | 1.007 (1.006-1.009) | 0.000 | 1.005 (1.002-1.007) | 0.000 | 1.007 (1.006-1.009) | 0.000 | 1.005 (1.003-1.007) |
| TBIL | 0.001 | 1.013 (1.005-1.02) | 0.004 | 1.010 (1.003-1.016) | ||||
| PT | 0.003 | 1.140 (1.047-1.242) | 0.002 | 1.116 (1.04-1.197) | 0.061 | 1.075 (0.997-1.159) | ||
| AFP (≤200 vs. >200) | 0.000 | 0.520 (0.406-0.666) | 0.011 | 0.701 (0.533-0.923) | 0.000 | 0.558 (0.458-0.68) | 0.000 | 0.634 (0.512-0.786) |
| HBV infection (NO vs. YES) | 0.688 | 0.942 (0.703-1.262) | 0.06 | 0.791 (0.62-1.01) | ||||
| Ascites (NO vs. YES) | 0.000 | 0.453 (0.312-0.657) | 0.002 | 0.595 (0.43-0.823) | ||||
| Hepatic cirrhosis (NO vs. YES) | 0.066 | 0.774 (0.589-1.017) | 0.09 | 0.830 (0.67-1.029) | ||||
| Child-Pugh grade (A vs. B) | 0.000 | 0.416 (0.273-0.634) | 0.009 | 0.598 (0.407-0.879) | ||||
| ALBI grade (I vs. II) | 0.000 | 0.481 (0.377-0.613) | 0.003 | 0.661 (0.503-0.869) | 0.001 | 0.711 (0.582-0.867) | ||
| Type of hepatectomy (Non-anatomic vs. Anatomic) | 0.000 | 0.566 (0.443-0.722) | 0.001 | 0.726 (0.596-0.883) | ||||
| Intraoperative blood loss | 0.000 | 1.000 (1.000-1.000) | 0.000 | 1.000 (1.000-1.000) | 0.109 | 1.000 (1.000-1.000) | ||
| Intraoperative blood transfusion (NO vs. YES) | 0.000 | 0.446 (0.346-0.575) | 0.000 | 0.477 (0.387-0.588) | 0.000 | 0.594 (0.456-0.774) | ||
| Maximum tumor size (≤5 vs. >5) | 0.000 | 0.325 (0.25-0.422) | 0.000 | 0.542 (0.403-0.729) | 0.000 | 0.496 (0.407-0.604) | 0.015 | 0.751 (0.596-0.947) |
| Tumor number (Single vs. Multiple) | 0.000 | 0.474 (0.365-0.616) | 0.000 | 0.574 (0.434-0.759) | 0.000 | 0.497 (0.401-0.617) | 0.000 | 0.582 (0.462-0.733) |
| Tumor differentiation (Moderate-well vs. Poor) | 0.000 | 0.315 (0.177-0.563) | 0.013 | 0.453 (0.242-0.849) | 0.001 | 0.537 (0.372-0.775) | 0.094 | 0.708 (0.473-1.061) |
| Satellite nodules (NO vs. YES) | 0.000 | 0.492 (0.348-0.696) | 0.000 | 0.537 (0.404-0.715) | ||||
| Macrovascular invasion (NO vs. YES) | 0.000 | 0.290 (0.221-0.38) | 0.010 | 0.662 (0.484-0.907) | 0.000 | 0.435 (0.341-0.555) | ||
| Microvascular invasion (NO vs. YES) | 0.000 | 0.330 (0.258-0.423) | 0.001 | 0.631 (0.477-0.834) | 0.000 | 0.379 (0.31-0.463) | 0.000 | 0.599 (0.475-0.756) |
| Postoperative complication (NO vs. YES) | 0.000 | 0.454 (0.342-0.603) | 0.032 | 0.714 (0.525-0.972) | 0.000 | 0.571 (0.448-0.729) | ||