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. 2022 Feb 15;12(2):793–804.

Figure 6.

Figure 6

Association between H2AX and metastasis in breast cancer. A. H2AX expression comparison between parental (MDA-MB-231) and lung metastatic clone (LM2-4) in human breast cancer cell line (n=3, each). B. H2AX expression comparison between parental (4T1) and bone metastatic clone (4T1.2) in murine breast cancer cell line (n=3, each). C. H2AX expression comparison between primary (n=13) and metastatic breast cancers (liver: n=14, lung: n=12, brain: n=10) in breast cancer cohort GSE110590. D. H2AX high expressing tumor fraction by stage in TCGA breast cancer cohort. Stage I: n=180, stage II: n=618, stage III/IV: n=269. E. H2AX high expressing tumor fraction by stage in METABRIC breast cancer cohort. Stage I: n=368, stage II: n=604, stage III/IV: n=105.