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. 2022 Mar 4;10(2):e002703. doi: 10.1136/bmjdrc-2021-002703

Figure 1.

Figure 1

Plasmatic miRNAs at first trimester of pregnancy associated with IS estimated by the Matsuda Index at the second trimester of pregnancy. The model has been adjusted for sequencing lanes and runs, as well as gestational age, maternal age and BMI at first trimester of pregnancy. Fold change in miRNA abundance is for the change of 1 AU of ln transformed Matsuda Index. Horizontal dotted line is the threshold for FDR-adjusted p-value ≤0.05. Names of miRNAs from the C19MC cluster are in blue. AU, arbitrary unit; BMI, body mass index; FDR, false discovery rate; IS, insulin sensitivity; miRNAs, microRNAs; NS, not significant.