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. 2022 Mar 4;10(2):e002703. doi: 10.1136/bmjdrc-2021-002703

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Pearson partial correlations between miRNAs, Matsuda Index and triglyceride levels. (A)-(E) DESeq2 normalized reads counts for top five miRNAs associated with IS, and Matsuda Index values were ln-transformed to normalize the distribution of data. The models were adjusted for gestational age, as well as maternal age and BMI at first trimester of pregnancy. Results were considered statistically significant at Bonferroni-adjusted p-value ≤0.01 (0.05 (p-value threshold)/5 tests). (F) DESeq2 normalized read counts and triglyceride levels were ln-transformed to normalize the distribution of data. The model was adjusted for gestational age, as well as maternal age and BMI at first trimester of pregnancy. Results were considered statistically significant at Bonferroni-adjusted p-value ≤0.0042 (0.05 (p-value threshold)/12 tests: four miRNAs and three lipids). BMI, body mass index; IS, insulin sensitivity; miRNAs, microRNAs.