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. 2022 Mar 4;9(1):e001808. doi: 10.1136/openhrt-2021-001808

Figure 4.

Figure 4

Importance of haemodynamic and cardiac imaging predictors of MACE: Importance of RHC and CMR imaging parameters in predicting the combined endpoint of death or heart failure hospitalisation. The relative importance was determined using Random Forest algorithm and is depicted in descending order of importance. Central Illustration: summary of key findings from our analysis. (A) PH is highly prevalent in cardiac amyloidosis (CA); while isolated post-capillary PH (IPC-PH) is most common, a substantial proportion of patients have combined post and pre-capillary PH (CPCPH). (B) Right ventricular dysfunction, as defined using RV ejection fraction and strain, correlates with amyloid burden as assessed by extracellular volume (ECV). (C) In Random Forest modelling, TPG, LVEF and RVEF were the most important variables in predicting major adverse cardiovascular events (MACE). CMR, cardiac magnetic resonance; DPG, diastolic pulmonary gradient; ECV, extracellular vol; EF, ejection fraction; LV, left ventricle; PA, pulmonary artery; PVR, pulmonary vascular resistance; RHC, right heart catheterisation; RV, right ventricle; TPG, transpulmonary gradient.