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. 2022 Mar 4;9(1):e001808. doi: 10.1136/openhrt-2021-001808

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Summary of key findings from our analysis. (A) PH is highly prevalent in cardiac amyloidosis (CA); while isolated post-capillary PH (IPC-PH) is most common, a substantial proportion of patients have combined post and pre-capillary PH (CPCPH). (B) Right ventricular dysfunction, as defined using RV ejection fraction and strain, correlates with amyloid burden as assessed by extracellular volume (ECV). (C) In Random Forest modelling, TPG, LVEF and RVEF were the most important variables in predicting major adverse cardiovascular events (MACE). DPG, diastolic pulmonary gradient; ECV, extracellular vol; EF, ejection fraction; LV, left ventricle; PA, pulmonary artery; PH, pulmonary hypertension; PVR, pulmonary vascular resistance; RV, right ventricle; TPG, transpulmonary gradient.