Table 3.
Comparison of CMR parameters across groups
| Entire cohort | PH group | P value | ||||
| N=52 | No PH (n=5) |
Pre-capillary PH (n=3) | IPC-PH (n=29) |
CpcPH (n=15) |
||
| Indexed LV mass (gm/m2) | 115.7±29.4 | 105.5±52.9 | 124.9±14.1 | 117.0±27.7 | 114.8±26.8 | 0.79 |
| Max wall thickness (mm) | 18.7±4.5 | 18.2±6.1 | 17.0±6.1 | 19.1±4.6 | 18.3±4.0 | 0.92 |
| LVEDVI (mL/m2) | 72.5 (62.9–86.2) | 60.2 (46.9–95.0) | 72.0 (70.5–92.2) | 75.8 (65.5–90.1) | 69.3 (61.3–73.8) | 0.24 |
| LVESVI (mL/m2) | 40.7 (32.9–50.4) | 24.4 (20.6–45.5) | 47.3 (44.8–56.8) | 41.3 (33.3–51.3) | 40.0 (36.3–48.3) | 0.13 |
| LVEF (%) | 43.0±12.9 | 53.9±17.0 | 35.4±17.6 | 42.6±11.9 | 41.7±11.8 | 0.54 |
| RVEDVI (mL/m2) | 76.1 (65.3–98.4) | 86.7 (48.2–92.7) | 110.0 (103.8–117.3) | 76.0 (66.4–96.0) | 73.5 (62.0–89.7) | 0.11 |
| RVESVI (mL/m2) | 47.0 (34.5–60.5) | 32.8 (26.0–51.9) | 75.5 (65.8–82.6) | 43.6 (37.5–57.7) | 51.4 (35.0–60.1) | 0.07 |
| RVEF (%) | 40.5±11.9 | 49.6±10.2 | 31.9±15.6 | 41.2±11.0 | 37.9±12.4 | 0.28 |
| Indexed LA volume (mL/m2) | 67.6±15.4 | 58.4±20.3 | 86.5±7.7 | 70.2±13.0 | 62.1±15.4 | 0.02 |
| Native T1 (msec) | 1109±71 | 1113±40 | 1090±14 | 1111±77 | 1108±79 | 0.53 |
| ECV (%) | 53.9±11.5 | 48.4±9.0 | 60.7±12.6 | 53.0±11.5 | 56.4±12.2 | 0.47 |
| Peak radial LV strain (%) | 15.6 (10.5–18.7) | 18.2 (11.6–26.7) | 15.7 (13.7–16.4) | 16.6 (10.3–20.9) | 13.7 (10.8–16.8) | 0.52 |
| Peak circumferential LV strain (%) | −11.2 (−15.9–−8.3) | −12.0 (−16.2–−9.0) | −11.5 (−11.7–−10.1) | −12.0 (−13.8–−8.3) | −10.3 (−12.1–−8.5) | 0.58 |
| Peak LV longitudinal strain (%) | −6.8 (−8.9–−5.4) | −6.7 (−6.8–−6.4) | −7.4 (−8.2–−5.8) | −6.9 (−9.5–−5.2) | −7.2 (−8.5–−5.6) | 0.99 |
| Peak RV radial strain (%) | 10.6 (7.6–14.2) | 17.3 (4.4–30.1) | 13.9 (6.3–21.6) | 10.9 (8.4–15.0) | 9.6 (7.0–10.7) | 0.55 |
| Peak RV circumferential strain (%) | −7.9 (−10.0–−5.9) | −10.4 (−17.2–−3.6) | −9.1 (−13.2–−5.0) | −8.2 (−10.8–−6.1) | −6.9 (−8.3–−5.9) | 0.61 |
| Peak RV longitudinal strain (%) | −12.9 (−16.5–−10.2) | −16.2±7.2 | −13.0±5.2 | −14.5±5.4 | −12.6±3.4 | 0.59 |
| Indexed LV mass (gm/m2) | 115.7±29.4 | 105.5±52.9 | 124.9±14.1 | 117.0±27.7 | 114.8±26.8 | 0.79 |
| Max wall thickness (mm) | 18.7±4.5 | 18.2±6.1 | 17.0±6.1 | 19.1±4.6 | 18.3±4.0 | 0.92 |
| LVEDVI (mL/m2) | 72.5 (62.9–86.2) | 60.2 (46.9–95.0) | 72.0 (70.5–92.2) | 75.8 (65.5–90.1) | 69.3 (61.3–73.8) | 0.24 |
| LVESVI (mL/m2) | 40.7 (32.9–50.4) | 24.4 (20.6–45.5) | 47.3 (44.8–56.8) | 41.3 (33.3–51.3) | 40.0 (36.3–48.3) | 0.13 |
| LVEF (%) | 43.0±12.9 | 53.9±17.0 | 35.4±17.6 | 42.6±11.9 | 41.7±11.8 | 0.54 |
| RVEDVI (mL/m2) | 76.1 (65.3–98.4) | 86.7 (48.2–92.7) | 110.0 (103.8–117.3) | 76.0 (66.4–96.0) | 73.5 (62.0–89.7) | 0.11 |
| RVESVI (mL/m2) | 47.0 (34.5–60.5) | 32.8 (26.0–51.9) | 75.5 (65.8–82.6) | 43.6 (37.5–57.7) | 51.4 (35.0–60.1) | 0.07 |
| RVEF (%) | 40.5±11.9 | 49.6±10.2 | 31.9±15.6 | 41.2±11.0 | 37.9±12.4 | 0.28 |
| Indexed LA volume (mL/m2) | 67.6±15.4 | 58.4±20.3 | 86.5±7.7 | 70.2±13.0 | 62.1±15.4 | 0.02 |
| Native T1 (msec) | 1109±71 | 1113±40 | 1090±14 | 1111±77 | 1108±79 | 0.53 |
| ECV (%) | 53.9±11.5 | 48.4±9.0 | 60.7±12.6 | 53.0±11.5 | 56.4±12.2 | 0.47 |
| Peak radial LV strain (%) | 15.6 (10.5–18.7) | 18.2 (11.6–26.7) | 15.7 (13.7–16.4) | 16.6 (10.3–20.9) | 13.7 (10.8–16.8) | 0.52 |
| Peak circumferential LV strain (%) | −11.2 (−15.9–−8.3) | −12.0 (−16.2–−9.0) | −11.5 (−11.7–−10.1) | −12.0 (−13.8–−8.3) | −10.3 (−12.1–−8.5) | 0.58 |
| Peak LV longitudinal strain (%) | −6.8 (−8.9–−5.4) | −6.7 (−6.8–−6.4) | −7.4 (−8.2–−5.8) | −6.9 (−9.5–−5.2) | −7.2 (−8.5–−5.6) | 0.99 |
| Peak RV radial strain (%) | 10.6 (7.6–14.2) | 17.3 (4.4–30.1) | 13.9 (6.3–21.6) | 10.9 (8.4–15.0) | 9.6 (7.0–10.7) | 0.55 |
| Peak RV circumferential strain (%) | −7.9 (−10.0–−5.9) | −10.4 (−17.2–−3.6) | −9.1 (−13.2–−5.0) | −8.2 (−10.8–−6.1) | −6.9 (−8.3–−5.9) | 0.61 |
| Peak RV longitudinal strain (%) | −12.9 (−16.5–−10.2) | −16.2±7.2 | −13.0±5.2 | −14.5±5.4 | −12.6±3.4 | 0.59 |
CpcPH, combined post and pre-capillary PH; ECV, extracellular vol; EDVI, Indexed end diastolic volume; EF, ejection fraction; ESVI, indexed end systolic volume; IPC-PH, isolated post-capillary PH; IPC-PH, isolated post-capillary PH; LA, left atrium; LV, left ventricle; PH, pulmonary hypertension; RV, right ventricle.