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. 2022 Feb 4;8:770491. doi: 10.3389/fmed.2021.770491

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Copyright © 2022 Swanson, Kochman, Amin, Chouhan, Yim, Engen, Shaikh, Naqib, Tran, Voigt, Forsyth, Green and Keshavarzian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circadian rest-activity cycles in inactive IBD by disease history and subclinical inflammation. Wrist Actigraphy was used to determine non-parametric variables—interdaily stability (IS), intradaily variability (IV), and relative amplitude (RA). relating to rest-activity circadian cycles. Disease History was compared to (A) IS, (B) IV, and (C) RA. IS and IV were increased in Aggressive IBD. IV associated was associated with increased (D) intestinal permeability and (E) TNF- α. Decreased RA was associated with (F) increased stool calprotectin.