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. 2022 Feb 4;8:770491. doi: 10.3389/fmed.2021.770491

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Copyright © 2022 Swanson, Kochman, Amin, Chouhan, Yim, Engen, Shaikh, Naqib, Tran, Voigt, Forsyth, Green and Keshavarzian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LEfSe analyses of significant fecal microbiomes of Patients with IBD and circadian wrist actigraphy alignments. LEfSe identifies bacterial (species) clades that are differentially abundant within IBD classification types [Crohn's disease (CD) or Ulcerative Colitis (UC)] circadian wrist actigraphy class and alignments subclass. (A) CD Interdaily Stability (IS) Low and High (B) CD Relative Amplitude (RA) Low and High; (C) CD Intradaily Variability (IV) Low and High; (D) UC RA; Low and High; and (E) UC IV Low and High. Clade colors: Low alignments (green) and High alignments (red). Clades in these graphs were both statistically significantly (P < 0.05) and exceeded an LDA log score of at least (± 2).